Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Dengue hemorrhagic fever (DHF) is an endemic disease affecting tropical countries. When there is a change in predominating serotype, large outbreaks will occur. In Vietnam, there has been a significant increase in the number of DHF cases in 2022. Therefore, this study was conducted to investigate whether there have been any changes in the distribution of dengue serotypes and the severity of DHF among children in Vietnam. This case series report was conducted at Children's Hospital 1 at Ho Chi Minh City from June 2022 to September 2022. Patients enrolled in the study were diagnosed with DHF based on WHO 2009 criteria and had positive RT-rPCR dengue results. Among 180 children enrolled in the study, 120 cases (66.7%) were caused by DENV-2, 58 (32.2%) by DENV-1, and 2 (1.1%) by DENV-4. The severity of disease varied, with the highest magnitude being DHF with warning signs (42.8%), followed by severe DHF (30.0%), and DHF (27.2%). DENV-2 infection was associated with more severe manifestations in terms of hemoconcentration (p=0.001), thrombocytopenia (p<0.001), abdominal pain (p=0,009), hepatomegaly (p=0,001). DENV-2 infection was more likely to result in shock compared to DENV-1 (p=0.036). DENV-2 was the predominating serotype, children infected with DENV-2 typically exhibited more severe manifestations compared to DENV-1. The relationship between shock, abdominal pain, hepatomegaly, hemoconcentration, thrombocytopenia, and dengue serotypes are statistically significant.
Abstract : The maternal mortality rate (MMR) in Indonesia is currently the highest in Southeast Asia, based on data from the 2015 Intercensal Population Survey (SUPAS) wich showed a maternal mortality rate of 305 per 100,000 live births and the direct causes of maternal mortality are caused by preeclampsia and bleeding. Antenatal care is one of the key interventions to reduce maternal mortality and achieve the Sustainable Development Goals (SDGs) targets that have been implemented in various countries. The aim of this study was to determine the factors that influence early screening of preeclampsia in pregnant women at the health centre. This research method was conducted using Systematic Literature Review by using academic journal search engines from online databases such as Pubmed, Web of Science, Scopus, and Springer Link published between 2012-2022. Results the findings of this study found that the factors most associated with early detection of preeclampsia were knowledge of pregnant women towards early detection of preeclampsia and acces to health services.
Abstract : Epilepsy is a prevalent neurological disorder often associated with negative connotations. Due to the nature of epileptic seizures, a social stigma persists around epilepsy. Epilepsy is more prevalent among vulnerable populations, who might be more affected by the psychosocial consequences of this stigma. Enhancing familiarity with epilepsy could significantly reduce its associated stigma. Therefore, evaluating the public’s knowledge and their attitudes toward the disease is essential. This study aims to assess the public’s knowledge of epilepsy, their attitudes toward it, and to compare our findings with previous similar studies. A cross-sectional study was conducted in early 2022 using an online survey. The survey collected socio-demographic variables, general knowledge about epilepsy, knowledge of first aid for seizures, and opinions and attitudes toward the disease. The survey was completed by 865 respondents, 465 of whom were males. The majority (82.3%) reported familiarity with the disease. Furthermore, most believed that epilepsy was not a barrier to employment (75%) or marriage (79.8%). More participants were willing to hire someone with epilepsy (66.2%) than to marry someone with the condition (32.9%). When questioned about their potential reactions to witnessing a seizure, the majority (N=674) reported that they would intervene. Our findings suggest that the public generally has a positive attitude toward epilepsy. However, there is a clear need to improve public un
Abstract : Abstract Viruses have evolved to become highly efficient at nucleic acid delivery to specific cell types while avoiding immunosurveillance by an infected host. Because of these characteristics, viruses are appealing gene delivery vehicles, or vectors, for gene therapy. Several viruses, including retrovirus, adenovirus, AAV, and herpes simplex virus, have been mutated for lab use in gene therapy applications. Because each of these vector systems has its own set of advantages and limitations, it is best suited to certain applications. Retroviral vectors can permanently integrate into the infected cell's genome, although transduction requires mitotic cell division. Adenoviral vectors may successfully carry genes to a wide range of dividing and nondividing cell types, but in vivo gene expression is generally limited by the immune clearance of infected cells. Herpes simplex virus can transport enormous quantities of foreign DNA; yet, cytotoxicity and transgenic expression maintenance remain challenges. AAV can infect both non-dividing and dividing cells, although it has a limited DNA capacity. On the other hand, Chimeric viral-vector systems, which combine favourable traits of two or more viral systems, are also being investigated. Although viral-mediated gene delivery has shown to be the most effective method of gene transfer, nonviral methods are also being researched. Many of these nonviral technologies combine elements of viral vectors to improve gene delivery or expression e
Abstract : Background: Thalassemia is a chronic, inherited blood disease that causes severe and transfusion-dependent anaemia. The disease burden affects patients' quality of life (QoL) and their families. Objective: To assess the caregivers’ burdens and their QoL. Patients and Methods: This quantitative–descriptive study was conducted from February 2022 to April 2023 in Sulaimani Thalassemia and Blood Disorder Center, Sulaimaniyah, Iraq, on 304 thalassemia patients’ caregivers. A validated questionnaire collected participants' data, including sociodemographic characteristics, caregiving-related factors, QoL, and caregivers’ burden points. Results: Participants mean age was 42.43 ± 8.12 years. Most of them (67.1%) were middle-aged (36-49 years), females (59.2%), housewives (56.6%), had no formal education (48.7%), their income was less than their expenditure (57.9%), and were mothers (61.8%). On the other hand, 23.7% had a chronic disease, did not perform the premarital test (81.6%), were ready to perform the antenatal test (63.2%), and 60.5% were prepared to abort the fetus if diagnosed as thalassemia. Regarding QoL domains, 68.4% had a poor physical domain, 67.1% of each environment domain, and overall QoL was poor; 59.2% had a poor psychological domain. In comparison, the proportion of poor social relations domain was 53.9%. Most (39.5%) had moderate to severe caregiving burdens, and 34.2% had severe caregiving burdens. A negative correlation was found between QoL and caregiving burd