Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Purpose: To evaluate the potential of autologous activated platelet-rich plasma (aaPRP) and the outcomes for treating severe Coronavirus Disease-2019 (COVID-19) patients in Intensive Care Unit (ICU). Materials and methods: A case series of four patients from Koja Regional Public Hospital (Koja RPH) whom admitted to the ICU due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Results: All patients had the initial symptoms of SARS-Cov-2 infection and became worse overtime, so the patients were admitted to ICU. Dyspnoea with low oxygen saturation was observed in all cases. All patients had comorbids for COVID-19. Severe COVID-19 was observed in all of patients, as they had increasing CRP level and low level of oxygen saturation. The outcome of this case study showed potential effectiveness of aaPRP as adjunctive severe COVID-19 treatment. Conclusion: Autologous activated PRP treatment could be feasible to apply in severe COVID-19 management.
Abstract : In Indonesia, the rate of HIV transmission from mother to child is the highest in the world due to the low coverage of HIV testing and therapy among pregnant women. This study examined published research on the prevention of mother to child HIV transmission (PMTCT) and its associated factors. A systematic review using ProQuest, Ebsco, PubMed, and SpringerLink databases for the period 2009-2019 found 12 relevant publications. Of pregnant women surveyed, 22-98% had an antenatal care (ANC) visit at least once; 7.3-99.4% received pre-HIV test counseling; 37.9-95.2% were advised to get tested for HIV; 6-97% were tested for HIV; 3.3-98% received their results; 22.1% received post-HIV test counseling; and 41-84.6% received antiretroviral (ARV). The factors influencing PMTCT were socio-demographics, distance to health care facilities, number of ANC visits, knowledge and awareness, partner engagement, stigma, and counseling. PMTCT publications were limited in terms of geographical coverage and none of the publications contained quality and sustainability aspects. There is a need to conduct research to improve the coverage of PMTCT in Indonesia as well as service quality and sustainability.
Abstract : This study aims to develop the Artificial Neural Network (ANN) through Multilayer Perceptron Neural Network (MLP) by considering the bootstrapping methodology. Applying the bootstrapping approach in MLP methodology improves the precision of the related urea level determination factor. This model developed to determine urea reading among diabetic patients. Three blood parameter Fasting Blood Glucose (X1), HbA1c (X2), and Sodium Reading (X3) were selected according to their clinical importance. All these parameters will be used as input for urea determination. Using The ANN-MLP Model the performance of analysis will be determined through the Predicted Mean Square Error (PMSE) obtained from (MSE-forecasts the Network). In this research paper, all possible combinations of input will be evaluated one by one. The performance of MLP was evaluated through the PMSE of the neural network for the (MSE-forecasts the Network) and special attention will be given for the smallest value of PMSE reading while running the analysis. In this study, PMSE is used as a measurement for the goodness of fit test of the obtained model. It can be used as a tool to measure how far the prediction value from the actual value. The smallest PMSE will indicate the excellent performance of the model. In conclusion, a combination of these three variables which were Fasting Blood Glucose (X1), HbA1c (X2), and Sodium Reading (X3) contributed significantly to the area level through the developed methodology.
Abstract : Pressure ulcer is a condition often found in chronically ill patients with prolonged immobilization. Infected pressure sore can inhibit wound healing, wound treatment and worsen the patient's condition. Wound infections in hospitals are commonly related to nosocomial infection and antibiotics resistance. This research evaluated the incidence, bacterial growth pattern and antibiotics sensitivity of patients with pressure ulcer in Soetomo Hospital Surabaya. A total of 35 patients were admitted to RSDS and 14 patients fulfilled the requirements to be analyzed. We analyzed 14 patients’ medical records admitted to Soetomo Hospital from 1 October 2019 – 31 January 2020, including demographic data, diagnosis, decubitus site and stages, bacterial culture and antibiotic sensitivity. 71.5% of the patient were male and 57.1% categorized as old adult. Encephalopathy was the most common diagnosis found in pressure ulcer patients. A total of 85.7% of pressure ulcers were developed in the sacral region. Out of 19 isolates, the most common bacteria found is E.coli, followed by E. faecalis, P. aeruginosa, and A. baumanii. Amikacin demonstrated a high sensitivity against the majority of gram-negative bacteria. E. coli were very sensitive to amikacin, imipenem and meropenem. Cefepime, ceftazidime, gentamycin, imipenem, and piperacillin-tazobactam were other antibiotics that showed 100% sensitivity to P.aeruginosa. Cefoperazone-Sulbactam was the only antibiotic very sensitive to A. baumanii.
Abstract : Abstract: Background: psoriasis is a multifactorial disease, where the genetic predisposition has a big role in the disease development. Rationale: few studies try to prove that null GSTM1 and GSTT1 associated with psoriasis development. Aim: to evaluate the role of null GSTM1 and GSTT1 on psoriasis development as a genetic risk factor. Material and method: diagnostic case-control study evaluate the availability and the role of polymorphic genotyping of GTMS1 & GTTS1in development of psoriasis, done in Thi-Qar University research unites , extended all-over the 2017. Equal number of well crossly matched psoriatic patients and control (100) of each group. Family history, smoking status , stressful event assessment and co-infection had been assessed well. Ethical consideration had been optimally taken from the ethical committee, ethical approval accomplished by verbal consents from all participants, P value < 0.05 consider as significant comparative cut. GSTT1, GSTM1and albumin genes had fully assessed by fully automated PCR, Deletion occurring when only albumin gene present without GSTM1or GSTT1. Result: among psoriatic patient the value of genotypes of GSTM1, GSTT1 and combined was present in a percent of (37,66 and 27%) while in control group (51,80 and 40%), that show significant difference, and role of protection was obvious, where the strength of association that expressed by odd's ratios that were less than one in all state of comparison.