Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Colchicine is a medication used to treat gout and Behçet's disease. A rapid, stable and sensitive reversed phase liquid chromatography method coupled with MS/MS detector was developed and validated for determination of Colchicine in human plasma, Colchicine and internal standard (Colchicine-D3) were usefully extracted from human plasma samples by using liquid-liquid extraction technique. Validation parameter was carried out for the chromatographic method used for determining Colchicine in plasma including: accuracy, precision, linearity, selectivity, stability, calibration curve, recovery. The mobile phase consisting of (85% methanol: 15% Ammonium chloride), column ACE C8, (50 X 2.1) mm, 5 µm, flow rate was 0.4 ml/min, retention time was 0.44 minute for colchicine and Colchicine- D3, and the total run time was 0.8 minute. The lower limit of quantitation was 0.05 ng/mL, the calibration curve was linear (R2 = 0.9985) over the range of (0.05 – 4.00) ng/ml. The intra- and inter day precisions for quality control samples were < 10.0%, and the intra- and inter day accuracies were in the range of (89.33-106.33) %. However, the current LC/MS method of colchicine could be applied for pharmacokinetic study in human plasma.
Abstract : To reduce acute postoperative pain in major abdominal surgeries, patient-controlled epidural analgesia (PCEA) has been considered the gold standard. However, in recent years, its safety is being questioned as despite its low incidence rate of serious complications, these complications are often very dangerous nevertheless. On the other hand, for minimally invasive surgeries (MIS) with estimated reduced postoperative pain, intravenous patient-controlled analgesia (IV PCA) is seen as a possibly more effective alternative due to the autonomy and satisfaction given to the patient. A systematic review of previous RCTs and clinical trials of patients undergoing abdominal MIS was done to compare acute postoperative pain, length of hospital stay, time to first flatus, and incidence of postoperative nausea and vomiting (PONV) between PCEA and IV PCA. During movement, pain scores consistently showed a lower pain score in the PCEA group rather than the IV PCA group, because epidural analgesia with local anesthetics blocks non-nociceptive stimuli on top of nociceptive stimuli. Only 1 study showed > 0.1 day difference in length of stay after surgery. The IV PCA group took a longer time to first flatus and showed a higher percentage of patients experiencing PONV than in the PCEA group. This review showed that incidence of severe complications in PCEA proves to be low and is therefore the best method to reduce postoperative pain in abdominal MIS.
Abstract : The Jakarta Health Office initiated the “Knock on Doors, Serve with Heart” (hereinafter called KPLDH standing for Ketuk Pintu Layani Dengan Hati) program with the main objective of serving the community with a heart to the fullest and preventing sick people from becoming poor. KPLDH is an effort by the government to bring health services closer to the community, especially in the promotional and preventive fields. This study aims to develop a construction variable model for the KPLDH Program Performance index to measure the effectiveness of the KPLDH public policy program in Jakarta using the Baldrige Framework approach. This evaluation implementation research aims to determine the level of success of a program or to determine the effectiveness of program implementation. This research was conducted in mix-method. The study was followed by 44 sub-district health centers in Jakarta with a total of 308 respondents who submitted the KPLDH Program Performance Index assessment using the Baldrige assessment method approach. The results of the KPLDH Program Performance Index assessment are 82,16% with the predicate level of Benchmark Leader at the excellent level. These results indicate the implementation of the program with a systematic, effective, and responsive approach to the derivatives of the policies that have been determined, and good to excellent integration is proven by analysis, learning and sharing of organizational best practices as a key management strategy.
Abstract : Hypercholesterolemia is a primary risk factor for cardiovascular disease. One of the natural food that can lower cholesterol is Spirulina. Spirulina contains several active ingredients, especially phycocyanin and β-carotene, which have antioxidant activity and anti-inflammatory activity. Spirulina will be mixed with Yogurt that can lower cholesterol as well. The purpose of this study was to evaluate the effect of Spirulina Yogurt (Spirulina platensis) on total blood cholesterol levels in patients with hypercholesterolemia. The study was used as a pretest-posttest randomized control trial experimental with a control group design. The population in this study was hypercholesterolemia patients (total cholesterol ≥200 mg/dl). Samples were taken by purposive sampling, a sample of 8 people in the treatment group, and 8 people in the control group. The treatment group was given Spirulina Yogurt (1gram/200ml/day), while the control group was given Yogurt (200ml/day) for 14 days. The results showed that there was no significant change in the value of the control group (p=0,074>0,05), but there was a significant change in the treatment group (p=0,017<0,05). There was no significant difference in total cholesterol between the treatment and control groups (p = 0,812>0,05). Therefore, further research is needed to determine the effective dose and period time of the study and the process of making Spirulina yogurt properly so that it can be effective in lowering cholesterol.
Abstract : Thalassemia patient has physical and emotional problems due to illness condition, routine treatment, and it will affect their Quality of life. To relieve problems of the thalassemia patients, nurses should modify the environment of the patients and family by using the transcultural nursing model. Methods: It used a quasi-experimental method with pre and post-test design. There were 64 families of thalassemia patients who were participated as the sample by purposive non-random sampling technique and divided equally into the intervention and control group. The result showed that the mean post-test score of Quality of life in the intervention group was 118.22 (SD = 16.62). Meanwhile, the control group was 81.94 (SD = 12.26). There were significant differences in Quality of life among patients between the intervention and the control group (p = 0.001). This research assessment focused on the cultural elements of Lenninger's transcultural nursing. It is concerned with the cognitive ability to know about the values, beliefs, and expression patterns used to guide, support, or provide individuals, families, or groups with the opportunities to sustain health, be healthy, develop and survive. The conclusion is that the transcultural nursing model's application influences the Quality of life of thalassemia patients. It is recommended to nurses who care the thalassemia patients should apply the model of transcultural nursing.