Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : ..
Abstract : Burns causes vasodilatation resulting in increased capillary hydrostatic pressure which causes increased capillary membrane permeability. This causes fluids and electrolytes in the intravascular out to the extravascular including Albumin, resulting in hypoalbuminemia. Hypoalbuminemia is a condition in which the albumin level in the blood is below 3.5 g / dl. Based on the National Formulary according to the 2017 Minister of Health regarding restrictions on the provision of infusion albumin, patients are given human albumin transfusion if the albumin level is less than 2.5 g / dl. A solution is needed to increase albumin levels other than through transfusion, provided that this albumin transfusion alternative is expected to be more economical and efficient than transfusion albumin which is notoriously expensive. Channa striata extract is a new product which is expected to be an alternative to this transfusion albumin. The aim of the study was to determine whether the administration of Channa striata extract capsules can increase the albumin levels in the blood in burn cases. This research uses a systematical review method by taking journals through various databases. The conclusion of this study is that Channa striata extract capsules can increase albumin levels in the body and accelerate wound healing in burn patients. The research that also found Channa striata extract capsules also decreases serum MDA levels and increasing nitrogen balance in a positive direction
Abstract : Melasma is a pigmentation disorder with a multifactorial etiology. This condition is still a challenge for the field of cosmetic dermatology because it is recalcitrant to therapy and has a high risk of recurrence. Among the various risk factors known to play a role in the development of melasma, thyroid dysfunction is common to be found in this condition. This review attempts to gather evidence to quarry the relationship between melasma and thyroid hormone regulation disorders. The available evidence suggests that melasma can be influenced by inflammatory conditions, increased oxidative stress, and stimulation of Adrenocorticotropic hormone (ACTH) and Melanocyte-stimulating hormone (MSH) via the hypothalamic pituitary thyroid (HPT) axis in hyperthyroid conditions. By further understanding the pathophysiological conditions in this disorder, treatment and prevention of melasma progression can be carried out more effectively.
Abstract : Type 2 Diabetes Mellitus (T2DM) is a common disease that describe within metabolic complication. In Iraq, the prevalence of T2DM about 1.4 million. In T2DM, the insulin resistance in liver cause decrease glycogen synthesis leading to fail glucose production. This defect perform enhances lipogenesis and proteins synthesis leading to free fatty acid accumulation on liver. This defect effected on liver function and leading to liver damage. Seventy two patients were participated (28 males and 44 females). Their ages ranged between 45-60 years old and the mean of BMI to patients 23.55± 4.56 kg/m2. The means of random blood glucose (RBG) and HbA1c 288.42±68.63 mg/dl, 9.08± 1.9% respectively. Thirty apparently healthy persons (12 males and 18 females) were selected as a control group. Their age ranges were comparable to that of patients and the mean of BMI equal 22.94± 3.15 kg/m2. The means of RBG and HbA1c 101.9±11.18 mg/dl, 5.03±0.63% respectively. There was no significant differences in ALT, AST and ALP in the diabetes group compared to the healthy group (P‐value > 0.05) and there was no significant changes between males and female patients in ALT, AST and ALP furthermore RBG and HbA1c. It was noted that RBG and HbA1c were significantly positively correlated with level of ALT AST and ALP . conclusion: there was no significant difference between liver enzymes and T2DM. Through these results, there is no relationship between diabetes mellitus and elevated liver enzymes.
Abstract : Abstract Background: Central precocious puberty refers to early activation of the hypothalamic-pituitary-gonadal axis and occurs in 1 in 5000 to 10,000 children. Aim of study: To investigate the epidemiological characteristics regarding the demographic, clinical presentation, etiology of central precocious puberty, mode of treatment and, MRI findings. Patients and Method: A cross sectional study that conducted at Pediatric Endocrinology Outpatient Clinic in Children Welfare Teaching Hospital / Medical City from 1st of November 2018 to 30th of October 2019. It included 83 patients presented to the hospital because of early pubertal development and diagnosed with central precocious puberty. History was taken from patients’ parents & file records. The following data were collected: age at time of onset of complain, gender, consanguinity, family history of similar conditions, main presenting symptom, mode of treatment, history of cranial irradiation, history of meningitis, and MRI findings. All patients underwent physical examination, based on physical findings, decision was made for additional evaluations. Results: In this study, 53% of patients aged > 6 years; 79.5% were females; consanguinity was positive in 33.7%; most common presentation in males was pubic hair (76.5%) and in females was thelarche (42.4%). Etiology in 84.8% of female patients was idiopathic, while idiopathic and CAH etiologies were presented in 94.2% of male patients (47.1% for each). Conclusion: Central pre