Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : The worldwide pandemic of Coronavirus disease 2019 emerged in December 2019 in Wuhan, China. Early identification of immunological biomarkers is a critical step for the disease diagnosis and progression in pursuance of classifying high-risk patients within the dearth of relevant information. Material and method In a retrospective study, the laboratory finding of 98 COVID19 positively diagnosed patients with ages ranged from 9 up to 77 years and administered to Prince Hamza Hospital, Amman, Jordan were used in the study. We have adopted the immunological parameters of WBCs, neutrophils, monocyte, basophils, D-dimer, CRP, and ESR as markers for anticipated diagnostic indicators. Results Laboratory findings of COVID-19 showed that total WBCs might not be affected with SARS-CoV-2 in the initial phase of the disease. While the lymphocyte, eosinophil, basophil and CRP gave a primary indication about the COVID-19 infection through lymphopenia, eosinopenia, basopenia and an increase in the CRP value. The results of total WBC give a highly significant positive correlation with neutrophils (p<0.05), negative correlation with eosinophil and ESR, and significant positive correlation with monocyte and CRP (p<0.05). The age of the patient gave a negative correlation with lymphocyte, a highly significant negative correlation with eosinophil (p<0.01), and a significant positive correlation with ESR and CRP (p<0.05). Furthermore, The ESR gave a significant positive correlation with age an
Abstract : Air is an environmental component needed for human survival. This means that the respiratory organs are constantly exposed to particles contained in the air, including harmful particles that interfere with health such as dust. As we know that the presence of dust in the industry. is something that is certain so that the dust must be controlled. On the other hand, the small scale industrial sawmill industry with thousands in number and spread in rural areas, this waste has not been utilized optimally. Sawdust can be used as a filter for air dust. The purpose of this study was to determine the effectiveness of various variations of wood sawdust in multiplex applications to reduce the level of Total Dust Particles. The type of research used is a quasi-experimental laboratory scale to be applied in the field. This study uses the Pretest-Posttest One Group design. Measurements were made using HVS with 24 study samples with 3 different thicknesses of 10 cm, 15 cm and 20 cm. The results showed a decrease in thickness of 10 cm by 2.31%, 15 cm by 4.01% and 20 cm by 9.08%. Statistical testing using the ANOVA test and obtained an alpha value of 0,000, it can be concluded that there is a relationship. Then it can be concluded that the most effective thickness is 20 cm.
Abstract : Despite the great vest of published research about covid19 viral infection, many issues are still not fully explored. Ophthalmic effect of COVID-19 still pose a challenge and controversy to health care providers. The current study aimed to investigate the Gulf Cooperation Council (GCC) nations perception of COVID-19 ophthalmological manifestations, during the pandemic era. This is a cross sectional study. It was self-reported, electronically distributed to people from GCC with special emphasis on Saudi Arabia. Data were collected from 3500 participants. Among them; (14.1%) have chronic general, and (33.5%) have ophthalmologic diseases. The majority of the study participants were knowledgeable about the different clinical manifestations of covid19 on different body systems. However, only (11.3%) of them were aware that eye symptoms could be the first clinical manifestation of covid19 infection. In addition, half of the participants are unaware that covid19 could be transmitted through eyes. In conclusion, the GCC inhabitance have a lesser perception and knowledge about covid19 ophthalmological affection and it is way of transmission. This may necessitate an effort of implementing extra comprehensive guidelines.
Abstract : Nigella sativa (NS) is a commonly used traditional medicine which has been shown to have anti-inflammatory and immunomodulatory properties especially thymoquinone. However, its supplementation in patients of clinical trials showed conflicting results. Objectives: To perform a meta-analysis regarding the effects of NS supplementation on immune-inflammatory parameters such as Th1, Th2, Th17, Treg, CD4, CD8, CD4/CD8 ratio. Methods: Relevant articles were systematically searched through PubMed/Medline, SCOPUS, and Google Scholar databases from inception until June 6, 2020. Information related to: author’s name and year, study location, target population, sample size, age of participants, number of participants in each groups, type and dose of NS supplements, study duration, and the main results were extracted from each study. To determine the effect estimates, data were assessed using fixed or random effect model. Results: 15 studies using 509 subjects were enrolled for meta-analysis. Our results found a significant reduction in Th17 cells (SMD -0.58 [-1.08, -0.34], p=0.02) following supplementation with NS. There was a significant increased in Treg cells (SMD 0.32 [0.01, 0.63], p=0.05) and CD4 (SMD 2.29 [0.27, 4.32], p=0.03) following NS supplementation. In addition, there was significantly higher ratio of CD4/CD8 (SMD 0.65 [0.30, 1.00], p=0.0003) following NS supplementation. Effects of NS on Th1 cells (SMD -0.04 [-0.56, 0.47], p=0.87), Th2 cells (SMD -0.08 [-0.49, 0.34], p=0.7
Abstract : Nigella sativa L. belongs to family Ranunculaceae. The constituent from the seeds of Nigella Sativa has been reported to possess antitumor, antioxidant, antibacterial, anti-inflammatory, hypoglycemic, central nervous system depressant, antioxidant, and immunomodulatory activities. Systemic Lupus Erythematosis (SLE) is a multisystemic inflammatory disease due to chronic autoimmune disease. Current therapy has not shown satisfactory results due to various side effects. Objective:To predict the potential of constituents from Nigella sativa as an anti-inflammatory drug and as a SLE novel therapy. Method: The compound contained in Nigella was obtained from Knapack Karaya web server. Nigella sativa’s potential as an anti-inflammatory is predicted using Pass Server and Way2Drug. The parameters analyzed were updated agonist factor macrophage colonies, Caspase 3 stimulants, Caspase 8 stimulants, TP53 expression enhancers, FABP5, apoptotic agoptics, and immunomodulators. Interaction Experiment Tool with Protein Interest, Search Tool 17 Interacting Chemicals (STITCH). Target protein prediction (HITPICK). Result: Pass Server Analysis shows that Nigella sativa can act as an anti-inflammatory and induce apoptosis through TP53 expression enhancer and Caspase stimulant (Pa > 0.3). STITCH analysis shows that the content of Nigella sativa, Carvacrol, Thymol, and Myristicin, are predicted to activate CASP3 (Caspase 3) to trigger apoptosis. Analysis of HITPICK Oleic acid compounds is predicted t