Sapporo Medical Journal

Abstract : n the context of searching for a new molecular markers that contribute to under standing the pathological mechanisms of breast cancer and this aims to develop targeted and promising treatment lines. Several experiment studies have clarified the role of Long non-coding RNA molecules in the occurrence of breast cancer. HOTAIR molecule as LncRNA molecule has been extensively studied as a tumer promoter by controlling of gene expression number of genes related to cancer at several molecular levels. This is done through experimental and interventional studies on breast cancer cell lines and tissues. In this study, we tried to approach its expression level in patient’s plasma and compare it to healthy controls.