Abstract : Abstract : Human Immunodeficiency Virus (HIV) infection can be caused damage to the immune system and leading to immunocompromised conditions, making the person more likely to get other infections. Myiasis is a maggots infestation in the human body, in immunocompromised conditions, it can lead to severe conditions and cause death. Human cerebral myiasis in HIV patients is a rare condition. HIV Infection and type 2 Diabetes Mellitus (DM) play a major role in immune system dysregulation which leads to immunocompromise. Hereby, we report those case with its management.