Abstract : This study was done to conduct a review on the occurrence of tooth loss and its associated factors during Supportive Periodontal Therapy (SPT) among periodontitis patients. A literature search was performed using four databases with multiple keywords within the interest of this research. Data collected from previous articles were from 2000 to 2019. Ten previous research from 2004 to 2019 were met the criteria. The occurrence of tooth loss in ten studies was 1587 teeth. The highest and the lowest occurrence were 12.26% and 0.38% respectively. The associated factors of tooth loss for each study showed different percentages and significances. Some studies have limited associated factors. Among all these factors, smoking, old age, male, and educational status were highly associated with the occurrence of tooth loss. The incidence of tooth loss during SPT among periodontitis patients in ten studies was 6.57 % and associated with age, sex, smoking status, and educational level. However, this study did not reach a definitive conclusion due to the heterogeneity among studies.