Abstract : This study aimed to determine the risk factors that affected the pulmonary function disorder of workers in the manufacturing industry. The research was observational with cross-sectional design, the population were 286 workers while the total sample were 150 workers in the production unit who have worked at least five years, and willing to become respondents. Data collected from interviews with workers and measurement of environmental parameters. Bivariate analysis used Chi-Square test and multivariate test using PLS-SEM (Partial Least Square- Structural Equation Modeling). The result of the bivariate showed that there were a significant correlation between the level of inhaled dust, the use of PPE, and nutritional status (p-value < 0.05 ) with pulmonary function disorder of workers and there are no correlation between total dust levels, gender, age, smoking habits, exercise habits, medical record, temperature, humidity, ventilation, and working period (p-value > 0,05). Multivariate test results (PLS-SEM) showed result of the dust exposure factors of 20.1%, physical environment of 11%, individual factors of 18%, and behavioral factors of 15.7% on pulmonary function disorder. The variable of workers pulmonary function disorder was affected by dust exposure, physical environmental factors, individual factors, and behavioral factors to 64,8%.