Author : Afnan Alobaidi,

Abstract : My paper about androgen receptor and autism which discuss one of many causes of autism which is low levels of gamma aminobutyric acid(GABA) neurotransmitter that result from low production of glutamic acid decarboxylase 65&67 enzymes from the expression process of GAD1&2 genes that needed in catalyzing glutamate to form how using acetyl L-carnitine will affect on androgen receptors number. Discussion: Androgen receptor is found in the brain,upon activation by binding of androgen hormones and by taking acetyl l-carnitine, the number of activated AR will increase.The DNA-binding domain of activated androgen receptors will act as transcription factors(zinc finger domain) that regulate the expression of GAD1-2 genes by binding to the regulatory region of GAD1&2 genes(DNA) which called enhancer during the transcription process that leads to enhancing the transcription process of GAD1-2 genes in order to increase the amount of GAD65&67 proteins (enzymes) produced from translation process of m-RNA to protein in order to use these enzymes to catalyse enough amount of glutamate to produce enough amont of GABA neurotransmitter to help in treating or reducing symptoms of autism.

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