Abstract : This study was conducted to determine the effect of oral extract of O. stamineus in the management of diabetes in normal and alloxan-induced diabetic rats. The rats were divided into four groups, with ten rats. Group A (control) consisted of normal rats that received 2 ml (10 ml/kg of body weight) of normal saline per day. In comparison, group B consisted of diabetic rats that received 1 ml (120 mg/kg of body weight) of treatment with extract of O. stamineus. On the other hand, Group C consisted of diabetic rats given 1 mL (150 mg/kg body weight) of metformin. On the other hand, Group D was made up of untreated diabetic rats who served as a negative control group. Alloxan (150 mg/kg body weight) was injected intraperitoneally into groups B, C, and D. Diabetic group B rats given O. stamineus extract had considerably lower blood glucose levels than diabetic group D rats (p = 0.05). Similarly, diabetic rats in group B consumed significantly less food and water than diabetic rats in group D (p = 0.05). After that, diabetic group B rats given O. stamineus extract had a considerable increase in body weight (p = 0.001). In conclusion, O. stamineus extract can reduce alloxan-induced hyperglycemia in diabetic rats and prevent weight loss in diabetic animals.