Sapporo Medical Journal

Abstract : In rheumatoid arthritis patients the risk of cardiovascular affection is 2–3 times higher than the general population, with increased morbidity and mortality. This is due to increase in the traditional and nontraditional risk factors. The aim of this study is to determine the cardiovascular risk in patients with RA using four established CV risk algorithms Framingham Risk Score (FRS), Systematic Coronary Risk Evaluation Score (SCORE], Reynolds Risk Score (RRS), Q II Risk Score and there relation with serum levels of leptin and interleukin-6 (IL-6). Methods:Cross sectional study was conducted during the period between December 2018 and June 2019 Sixty seven RA patients were enrolled in this study. The 10-year CVR for RA patients were calculated using FRS, SCORE, RRS and Q II Risk Score. Serum leptin and IL-6 were estimated. Results:The results showed a significant difference between higher leptin values and disease activity, obesity, positive RF and longer disease duration, On the other hand, we found a significant difference between higher IL-6 values and disease activity, and hypertriglyceridemia. As regarding correlations of IL-6 and Leptin with different cardiovascular scores, there were no significant correlations with exception of moderate significant correlation between IL-6 and RRS (r= 0.42, P< 0.001). Conclusion:We found no correlation between CVR scores and leptin or IL-6 except for RRS and IL-6, therefore new models of CVD risk prediction incorporating RA specific