Abstract : Abstract— Background: SARS-CoV-2 patients with obesity have a high risk for severe and critical clinical conditions that require intensive care and have a poor chance of outcome. The aim of this study was to determine association of obesity with length of stay and mortality of SARS-CoV-2 patients in a national referral hospital Indonesia. Methods: This study used a retrospective cohort. The research sample was SARS-CoV-2 patients who were treated by pulmonary specialists in the intensive room of Dr. M. Djamil Hospital Padang. The number of samples in this study was 100 subjects. The inclusion criteria in this study were patients aged > 18 years and patients with severe and critical clinical SARS-CoV-2 confirmed who were undergoing treatment in the SARS-CoV-2 isolation intensive room for the period January – December 2021 and there were data on weight and height in the initial assessment on medical record. Data analysis was performed using the Chi-square test. P < 0.05 was significant, and the data were analyzed using the SPSS version 21.0 program. Results: SARS-CoV-2 patients with obese who had a length of stay ≥ 14 days (25.0%) more than non-obese (9.6%). This study found that there was an association between obesity and length of stay of SARS-CoV-2 patients (OR = 3.13, 95% CI 1.01-9.70). The majority of obese patients died (81.3%) more than non-obese (57.7%). This study found that there was an association between obesity and mortality of SARS-CoV-2 patients (OR = 3.18, 95%