Abstract : Urinary tract infection (UTI) is one of the most common complications found in managing patients in the field of urology. The biggest challenge in UTI management is antibiotic resistance. In this study, patient data were taken retrospectively from urology patients in 1 year. A total of 643 patients were tested for urine culture, with the most cases of urinary tract stone (35.5%). Escherichia coli was the most common bacteria. Cefoperazone sulbactam (91%) was the most sensitive parenteral antibiotics used for the patients, whereas Fosfomycin (85.3%) was the oral antibiotics of choice. Aminoglycoside, Carbapenem groups, Cefoperazone sulbactam, and Piperacillin tazobactam antibiotic groups had a sensitivity level of more than 50% in treating urology patients with UTI. On the other hand, Cephalosporin and Quinolone were discovered to have a lower level of sensitivity. The use of a urinary catheter and DJ stent possibly contributed to the increase of antibiotics resistance. A total of 107 patients (16.6%) were discovered to be infected by Extended-Spectrum Beta-Lactamase (ESBL)-producing bacteria, especially among patients with urethral stricture.