Abstract : Abstract— Purpose: The aim of this study was to evaluate the bite force value between patients wearing PEEK frameworks fabricated by CAD-CAM in mandibular hybrid screw retained implant-supported prosthesis with all on four concepts. Materials and Methods: This study was a comparative clinical trial. It was conducted on six completely edentulous patients, according to the calculated sample size each patient received hybrid prostheses reinforced with PEEK framework. Biting force was assessed by a bite force transducer. All assessments were carried out three months after hybrid denture insertion as follows: - 1 week, 1 month, 3 months follow-up periods Results: The mean ±SD of bite force for peek group is 91.50±2.38 at 1 week ranging from 88.48 to 93.51, 88.43±4.37 at 1 month ranging from 80.22 to 92.4, 90.69±2.61 at 3 months ranging from 85.93 to 93.08. The repeated Measures test was used to assess change in bite force during follow-up from 1 week to 1 month to 3 months and demonstrates statistically non-significant difference between different follow up periods. Conclusion: Within the limitation of this study, the bite force value increases over time. The use of PEEK is very important in improving the bite force value and has proven highly effective in these cases