Abstract : The aim of this study was to evaluate the bite force value time through out between patients wearing Glass fiber reinforced composite resin frameworks fabricated by CAD-CAM in mandibular hybrid screw retained implant-supported prosthesis with all on four concept. Materials and Methods: This study was a comparative clinical trial. It was conducted on six completely edentulous patients according to the calculated sample size each patient received hybrid prostheses reinforced with Glass fiber reinforced composite resin framework. Biting force was assessed by a bite force transducer. All assessments were carried out nine months after hybrid denture insertion as follows: - 1 week, 1 month, 3 months, 6 months, 9 months follow-up periods Results: The mean ±SD of bite force for glass fiber is 82.25±9.18 at 1 week ranging from 68.75 to 91.67 , 88.49±6.31 at 1 month ranging from 76.14 to 92.06 , 90.59±3.95 at 3 months ranging from 83.04 to 93.85, 93.96±3.66 at 6 months ranging from 88.12 to 96.04 and 96.02±4.02 at 9 months ranging from 91.03 to 99.06. The repeated Measures ANOVA test was used to assess change in bite force during follow up from 1 week to 1 month to 3 months to 6 months to 9 months and demonstrates statistically significant difference between different follow up periods. Within the limitation of this study, the bite force value increases over time. The use of glass fiber is very important in improving the bite force value and has proven highly effective in these cases.