Abstract : During the 2019 coronavirus disease (COVID-19) pandemic, burnout emerges as a critical health problem that might involve workers in many occupations, particularly healthcare personnel. Although burnout syndrome is not necessarily proved to be nosologic, it yields serious physical, mental, and social outcomes. However, it is essential to provide practical strategies and effective tools for people so that they can adapt to such highly stressful situations. This mini literature review aims to present the burnout history briefly and provides a summary of its major effects, causes, and prevalence among healthcare workers. Also, some strategies are listed to be employed by hospital medical staff and organizations to deal with the COVID-19 pandemic.