Abstract : The outbreak of COVID-19 had a significant impact in terms of economic and social health. Because of the high mortality rate and the emergence of this health emergency condition, all scientists worldwide are attempting to investigate all types of biomarkers and markers that can be used as good indicators of symptoms, therapy, prognosis, and outcome COVID-19 patients. This study aims to compare Ferritin and CRP (C-Reactive Protein) levels in COVID-19 patients treated with pneumonia who survive and do not survive in the ICU Infection Center at Wahidin Sudirohusodo Hospital. The research uses a quantitative design with a cross-sectional study approach. The sample was taken from COVID-19 patients treated with pneumonia. Both survived and did not survive in the March-September 2020 period at the ICU Infection Center, Dr. Wahidin Sudirohusodo in Makassar. The research found no relationship between CRP levels and the ability to survive in the study sample group. Meanwhile, the ferritin levels of patients in the survival and non-survival groups showed a significant difference. The ferritin results in patients who did not survive were much higher than the ferritin levels in surviving patients. In this study, it was found that Ferritin is an essential factor affecting the severity of COVID-19. Ferritin is one of the factors that can be used as an indicator to assess the severity of patients with COVID-19

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