Author : Astrid Fransisca Padang, Tjokorda Gde Agung Suwardewa, I Gusti Kamasan Nyoman Arijana,

Abstract : The incidence of premature rupture of membranes is approximately 12% of all pregnancies, although this varies between 2-18% of pregnancies. The pathogenesis and epigenetic aspects of premature rupture of membranes are still unclear. lncRNA, ADAMTS15 mRNA and collagen are associated with premature rupture of membranes (PROM). Thus, this study would like to analyze the correlation of lncRNA BF328678, ADAMTS15 mRNA expression and collagen levels in premature rupture of membranes. The samples taken from two groups of subject, that consist of 20 people with premature rupture of membranes and 20 people without premature rupture of membrans. The mean of lncRNA expression in spontaneous labor with premature rupture of membranes is: 139.1 + 28.94, compared to spontaneous labor without premature rupture of membranes, is: 267.2 + 55.84, with p < 0.05. The mean of ADAMTS15 mRNA expression in spontaneous labor with premature rupture of membranes is: 39.4 + 10.01, compared with the results of expression on spontaneous labor without premature rupture of membranes, is: 6.95 + 2.32, with p < 0.05. The mean of collagen levels in spontaneous labor samples with premature rupture of membranes is: 5.92 + 1.95, compared to spontaneous labor without PROM, is: 6.95 + 2.32, with p < 0.05. It can be concluded that premature rupture of membranes increased expression of ADAMTS 15 mRNA.

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