Sapporo Medical Journal

Abstract : Background: Insulin resistance and hypertension is a tightly associated morbid-related disease through similar pathophysiological pathway. The increase of insulin resistance in sedentary office workers increase the risk of hypertension and cardiovascular disease. This study aimed to investigate the profile and correlation of insulin resistance and blood pressure in office workers in Indonesia. Methods: Participants were recruited and obtained informed consent for the study. The participants were first asked regarding smoking and physical activity. The participants were then measured for their blood pressure and extracted venous blood for evaluation of fasting blood glucose and fasting insulin level. The data were statistically analyzed with univariate analysis and bivariate analysis of correlation using Spearman test. Results: A total of 93 participants were included in the study. The mean age of the participants were 38.73±1.12 years. The participants’ data were centered in the profile of obese grade I, normal profile of insulin resistance, and normal profile of blood pressure. There was a significant weak correlation of insulin resistance with systolic blood pressure (r=0.361; p<0.001) and diastolic blood pressure (r=0.289; p=0.005). Conclusion: Insulin resistance shows a weak significant correlation with elevated blood pressure.