Abstract : The outbreak of coronavirus disease 2019 (COVID‐19), a respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), began in December 2019 in Wuhan, Hubei province, spreading across China and then globally. The D-dimer concentrations of patients with COVID-19 in the third trimester were found relatively higher than those of uninfected pregnant women. This report aim to summarize the current evidence of D-dimer level in pregnant and non-pregnant woman with and without Covid-19. On December 5, 2022, two databases including ScienceDirect and PubMed was searched to review and mine the latest published information about pregnancy, Covid-19, and D-dimer in the literature. After screening articles by removing duplicates and reading the abstract, 34 studies were considered to be relevant and included in this systematic review. Collected 23 about D-dimer level in pregnant woman with Covid-19 infection, 4 studies about D-dimer level in pregnant woman with Covid-19 infection vs pregnant woman without Covid-19 infection, and 7 studies about D-dimer level in pregnant woman with Covid-19 infection vs non-pregnant woman with Covid-19 infection. In view of fact that D-dimer level is high in pregnant patients, pregnant patient with covid-19 infection, and pregnant patient with severe symptomatic Covid-19 infection. D-dimer monitoring will be important in the clinical practice of pregnant woman with Covid-19 infection.