Abstract : Various devices have employed for percutaneous closure of Patent Ductus Arteriosus (PDA). Although effectiveness of device closure has been determined, a few studies focused on the cost-effectiveness and postoperative complications comparison with open surgery. This study aims to evaluate of PDA occlusion by Amplatzer Ductal Occluder in comparison with open surgical closure. A cross sectional study was performed in children with PDA whom underwent interventions. The interventions including Amplatzer Ductal Occluder and open surgical closure, data of demographic, characteristic PDA, length of stay, costs, interventions, outcome and complication were collected from medical record. Eighteen children (4/18 male) were diagnosed with PDA. The median age was 6.0 years, (SD 9.98). Most of patient suffered from moderate PDA (13/18) and large PDA (5/18). Interventions including Amplatzer ductal occluder (9/18) and open surgical closure (9/18) was found. The surgical group have experienced to care in ICU during hospitalized (9/18, median 0.5-day, p<0.01). The length of stay during hospitalized was longer in surgical group (median 5.5-days, p<0.01). The calculated costs were higher in surgical group (median 28.099.500 IDR, p=0.04). No event of mortality was observed in both of group. Amplatzer Ductal Occluder was more preferable because of its lower inexpensive and complication than surgical technique.