Sapporo Medical Journal

Abstract : Background: Chronic kidney disease (CKD) cases frequently experienced anaemia because of iron restriction and inflammation. Iron supplements, erythropoiesis-stimulating agents (ESAs) and, in extreme circumstances, red blood cell transfusions are options being used to treat anaemia caused by chronic kidney disease. Objective: to investigate the relationships between ESA resistance and gender, BMI, albumin, and the normalised protein catabolic rate. Methodology: Over the course of more than three months, ninty seven patients aged eighteen to seventy five who have been receiving steady haemodialysis treatment at the haemodialysis unit at Theodor bilharz research institute (TBRI).The medical histories as well as physical examinations of all patients were thoroughly documented, down to the patient's age, gender, race, whether or not they had received EPO, and the patient's EPO dosage in units per week. Weight and height were assessed as well as BMI was determined as weight/height (kg/m2). Results: Our data showed that the mean ERI was 14.8 U/kg/week EPO/Hb g/dL, that there was no link between ERI and gender, ERI and urea levels showed negative correlation before and after dialysis (p= 0.013), creatinine levels (p= 0.002), BMI (p= 0.016), and N-PCR (p= 0.034)and highly statistically negative correlation between ERI and haemoglobin level(p<0.001)and serum albumin(p<0.001),ERI and CRP showed highly statistically positive correlation(p<0.001). Conclusion: EPO hypo-responsiveness wa