Abstract : Congenital heart disease causes pulmonary arterial hypertension, heart failure, and early death. Pulmonary arterial hypertension causes pulmonary arterial wall remodeling, inflammation, deposition of extracellular matrix protein, collagen synthesis, and fibrosis. This study aims to analyze the effect of Pomegranate extract on pulmonary arterial pressure in Sprague Dawley rats with pulmonary arterial hypertension. Twenty-four Sprague Dawley rat age 3-month bodyweight 250-350 gram allocated randomly into Pomegranate extract and control group, 6 rats in each group. Pulmonary arterial hypertension.was induced with monocrotaline 60 mg/kg body weight injected subcutaneously. Pulmonary arterial pressure both groups were measured at 2 weeks and 4 weeks of observation. Rats were euthanized after 2 and 4 weeks of observation. Mean pulmonary arterial pressure the Pomegranate extract group was significantly lower compared to the control group in two weeks and four weeks of observation, 27,57±9,17 mmHg vs 47,48±5,58 mmHg (p=0.001) and 32,43±9,64 mmHg vs 46,53±5,53 mmHg (p=0.001) respectively. Pomegranate extract can decrease pulmonary arterial pressure in Sprague Dawley rats with pulmonary arterial hypertension induced by monocrotaline. Pomegranate extracts effective preventing the progressivity of pulmonary arterial hypertension in the rat.