Sapporo Medical Journal

Abstract : Abstract Background: Central precocious puberty refers to early activation of the hypothalamic-pituitary-gonadal axis and occurs in 1 in 5000 to 10,000 children. Aim of study: To investigate the epidemiological characteristics regarding the demographic, clinical presentation, etiology of central precocious puberty, mode of treatment and, MRI findings. Patients and Method: A cross sectional study that conducted at Pediatric Endocrinology Outpatient Clinic in Children Welfare Teaching Hospital / Medical City from 1st of November 2018 to 30th of October 2019. It included 83 patients presented to the hospital because of early pubertal development and diagnosed with central precocious puberty. History was taken from patients’ parents & file records. The following data were collected: age at time of onset of complain, gender, consanguinity, family history of similar conditions, main presenting symptom, mode of treatment, history of cranial irradiation, history of meningitis, and MRI findings. All patients underwent physical examination, based on physical findings, decision was made for additional evaluations. Results: In this study, 53% of patients aged > 6 years; 79.5% were females; consanguinity was positive in 33.7%; most common presentation in males was pubic hair (76.5%) and in females was thelarche (42.4%). Etiology in 84.8% of female patients was idiopathic, while idiopathic and CAH etiologies were presented in 94.2% of male patients (47.1% for each). Conclusion: Central pre