Abstract : Background - Stroke is a disease with the highest mortality rate and high treatment billing disease in Indonesia. The prevalence of ischemic stroke (IS) is the greatest among all types of stroke where the incidence is 85% of the total stroke [9]. In general, the purpose of this study was to understand the variation in billing in ischemic stroke inpatient services based on the determinant factors that influence it. Methods - The study design was a Non-Experimental Research Design with retrospective data from October to December 2019 and the unit of analysis was ischemic stroke patients who were treated at the National Brain Center Hospital (RS PON) Prof. Dr. dr. Mahar Mardjono Jakarta. Analysis is used to see the determinant factors that influence the variation in billing strokes. Results - The results of the study are expected to get an overview of billing variations influenced by the determinant factors observed, namely age, length of treatment (days), NIHSS score, comorbid (hypertension, tryglicerid and LDL), give positive contribution. While gender, speed of getting treatment after attack (hours), comorbid (diabetes, total cholesterol, HDL) are giving negative contribution. Conclusion - After descriptive analysis shows that hypertension, fasting glucose, LDL, length of stay and NIHSS score have an influence on total billing. However, after regression analysis showed that length of stay and NIHSS score were the variables that most influenced the variation in total ischemic