Abstract : The maternal mortality rate (MMR) in Indonesia is currently the highest in Southeast Asia, based on data from the 2015 Intercensal Population Survey (SUPAS) wich showed a maternal mortality rate of 305 per 100,000 live births and the direct causes of maternal mortality are caused by preeclampsia and bleeding. Antenatal care is one of the key interventions to reduce maternal mortality and achieve the Sustainable Development Goals (SDGs) targets that have been implemented in various countries. The aim of this study was to determine the factors that influence early screening of preeclampsia in pregnant women at the health centre. This research method was conducted using Systematic Literature Review by using academic journal search engines from online databases such as Pubmed, Web of Science, Scopus, and Springer Link published between 2012-2022. Results the findings of this study found that the factors most associated with early detection of preeclampsia were knowledge of pregnant women towards early detection of preeclampsia and acces to health services.