Author : Mostafa Talaat Abd-El Hakeem,

Abstract : Purpose: The aim of this study was to assess the ability of topical use of autologous platelet rich plasma (PRP) to improve success rate of myringoplasty. Patients and Methods: This investigation was led to the ENT Department at Minia University Hospital and included 30 patients with different sizes, dry, central tympanic membrane perforation, attending the E.N.T. outpatient clinic. Half the patients underwent fat graft myringoplasty (group A), while others received the fat graft with PRP (group B). Results: The graft was taken in 13 patients (86.7%) in group A, and in 14 patients (93.3%) in group B. Healing time was shorter in group B (2 months) than in group A (3 months). There was insignificant different between the two graft types in hearing gain, but in each graft type there was significant decrease in the mean ABG postoperatively. Conclusion: Effective autologous PRP application during myringoplasty has favorable healing results in small, medium sized and large central perforations

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