Abstract : Abstract. The aim of the study is to evaluate the dependence of associations of ST2 and Troрonin I levels on the nature of the anatomical lesion of the coronary arteries. Materials and methods. We examined 200 patients with NSTEMI aged 38 to 80 years, who were urgently hospitalized in the Vinnytsya Regional Clinical Center of Cardiovascular Pathology. All patients underwent laboratory testing of ST2 and Troponin I levels in plasma by enzyme-linked immunosorbent assay on the first day of hospitalization before coronary angiography. Results. In the association of relatively high levels of ST2 and relatively high levels of Troponin I, there is a positive correlation between the degree of coronary arteries damage, while in the association of relatively low levels of ST2 and Troponin I, severe stenotic coronary arteries lesions can be ruled out. Conclusions. Determining the associations of ST2 and Troponin I before coronary angiography allows to predict the degree of stenotic lesions of the coronary arteries and to determine the expected intervention strategy in patients with NSTEMI. Keywords: NSTEMI, Troponin I, ST2, coronary arteries.