Abstract : Heterotopic ossification (HO) is a rare preventable debilitating complication of immobility. We reported 2 cases of traumatic brain injured patients who has been bedridden and subsequently develop HO at bilateral hips for case number one and at unilateral elbow for case number two. Although they had a good cognitive recovery, the HO had hinder their everyday mobility and living activity potential. The interdisciplinary medical discussion with the patients had led to surgical removal of the heterotopic ossifications in both cases. Their quality of life improved tremendously following the intervention. This article illustrates the importance of a multidisciplinary approach and knowledge of various methods in the management of multiple disabilities that can help to achieve a realistic meaningful goal for the patients.