Abstract : Abstract—Objectives: The underlying immunological mechanisms of asthma in pregnancy are not fully understood. Pregnant women who tend to be allergic, exposure to several antigens causes activation of Th2 cells and production of Immunoglobulin E (IgE). This study aims to determine the differences of IgE levels in uncontrolled asthma, partly controlled, well controlled and women without asthma in pregnancy. Methods: This was a case control study conducted in Makassar Indonesia from November 2020 - June 2021. IgE levels were measured from blood samples and asthma control determined by GINA criteria. Result: Women with Asthma in pregnancy were 40 and 40 non asthma in pregnancy. Subject of asthma in pregnancy were 14 uncontrolled, 16 partly controlled and 10 well controlled. The mean age was not different between women with asthma in pregnancy and pregnant women without asthma ((28.025 + 5.17 vs 28.025 + 4.26). IgE levels were higher in pregnant women with asthma than pregnant women without asthma (529.8 + 688.11 vs 66.77 + 119.09 IU/mL: p=0.001). Serum IgE levels were higher in uncontrolled asthma compared with partly controlled (801.02+ 170 vs 476.93 + 143 IU/mL). IgE levels were higher in partly controlled asthma compared with well controlled (476.93 + 143 vs 72.75 + 26.47; p value = 0,001). Conclution: IgE levels were higher in women with asthma pregnancy compared with pregnant women without asthma and the highest levels of serum IgE levels were found in uncontrolled asthma.