Abstract : Children with ASD have a form of social interaction disorder, have limited communication, and repeatedly fidget. In Indonesia, it is estimated ASD occurs in 1 in 88 children. This research aims to find out more about the correlation between the history of pregnancy, birth and baby characteristics, and children with ASD. Researchers analyzed 112 children with ASD below the age of 10 based on inclusive and exclusive criteria from 3 therapy centers, Bina Autis Mandiri, YPAC, and SDLB in October and November of 2017. The Case-Control method was used in this research. Samples of some ASD cases have been taken from a therapy center in Palembang recently. From 112 samples (35.7% girls, 64.3% boys), we can conclude that gender, mother’s occupation, and race are factors of ASD (p<0.005) History of pregnancy such as age during the marriage, bleeding, APGAR score, age during pregnancy, the weight of the newborn and history of the birth of twins. The factors that lead to the birth of children with ASD are the mother’s age during the first pregnancy, bleeding, the birth process, age of pregnancy of the child with ASD, the weight of the newborn with ASD, APGAR score, and birth disorder. Having a checkup before pregnancy and antenatal care are some of the ways to prevent a child from getting ASD.