Sapporo Medical Journal

Abstract : The worldwide pandemic of Coronavirus disease 2019 emerged in December 2019 in Wuhan, China. Early identification of immunological biomarkers is a critical step for the disease diagnosis and progression in pursuance of classifying high-risk patients within the dearth of relevant information. Material and method In a retrospective study, the laboratory finding of 98 COVID19 positively diagnosed patients with ages ranged from 9 up to 77 years and administered to Prince Hamza Hospital, Amman, Jordan were used in the study. We have adopted the immunological parameters of WBCs, neutrophils, monocyte, basophils, D-dimer, CRP, and ESR as markers for anticipated diagnostic indicators. Results Laboratory findings of COVID-19 showed that total WBCs might not be affected with SARS-CoV-2 in the initial phase of the disease. While the lymphocyte, eosinophil, basophil and CRP gave a primary indication about the COVID-19 infection through lymphopenia, eosinopenia, basopenia and an increase in the CRP value. The results of total WBC give a highly significant positive correlation with neutrophils (p<0.05), negative correlation with eosinophil and ESR, and significant positive correlation with monocyte and CRP (p<0.05). The age of the patient gave a negative correlation with lymphocyte, a highly significant negative correlation with eosinophil (p<0.01), and a significant positive correlation with ESR and CRP (p<0.05). Furthermore, The ESR gave a significant positive correlation with age an