Sapporo Medical Journal

Abstract : Introduction: Drug-drug interactions (DDIs) present a significant challenge for patients, as concurrent medication use can lead to adverse effects. Early detection can mitigate these complications, and clinical pharmacists play a key role in providing guidance and facilitating communication with physicians. Objective: This study aimed to assess the prevalence of DDIs and evaluate the pharmacist's role in monitoring these interactions at Shar Hospital’s neurology department in Sulaimani, using free drug interaction checker mobile applications. Patients and Methods: A prospective observational and interventional study was conducted at Shar Teaching Hospital, Sulaimani, from Nov. 2021 to Feb. 2022. The observational phase assessed DDI incidence and types in patients admitted to the neurology ward. In the interventional phase, clinical pharmacists reviewed high-risk patients’ medications, identified potential interactions, and recommended interventions, such as dose adjustments, alternative medications, or additional monitoring. The impact of these interventions on reducing DDIs and improving outcomes was then evaluated. Results: The study found that 41.1% of patients used 3-5 drugs, while 37.4% used 6-10 drugs. Among the cases, 50.5% showed no interactions, 39.5% had minor interactions, and 3.7% had significant interactions. DDIs accounted for 49% of all interactions. Of the prescribed medications, 50.5% required no intervention, while 49.5% did, with 15.8% of these cases being