Sapporo Medical Journal

Abstract : This assessment was away for investigating lycopene activity on cyclooxygenase and lipid peroxidation in dexamethasone-treated Wistar rodents. Twenty (20) male Wistar rodents weighing between 150g-250g were aimlessly picked into four get-togethers containing five rodents each. Control rodents got standard feed and water. Social affair two got 3mg/kg body weight of dexamethasone intraperitoneally at regular intervals for 9 days. Social affair 3 got 3mg/kg body weight of dexamethasone intraperitoneally at regular intervals for 9 days notwithstanding step by step oral association of 1mg/kg of lycopene for 28 days. Results showed that there was no basic qualification in the activity of dexamethasone and lycopene on COX and THX-A 2 in all of the social affairs. Dexamethasone extended AST ALT and ALT level. Treatment with Lycopene in a general sense (p<0.01) lessened AST, ALT, and ALP in all of the social events. Lactate dehydrogenase development was generally (p<0.01) lessened in the dexamethasone and further carried downward on treatment with lycopene when appeared differently in relation to the DEX gathering. Malondialdehyde (MDA) obsession in Dex was extended (p<0.01), Catalase activity was lessened while SOD center was not changed. Treatment with lycopene Significantly (p<0.01) reduced serum MDA and extended catalase obsession. Triglyceride and LDL sections of the lipid were brought up in Dex with a decreased HDL anyway without alteration in complete cholesterol level. Lycopen