Sapporo Medical Journal

Abstract : Melasma is a pigmentation disorder with a multifactorial etiology. This condition is still a challenge for the field of cosmetic dermatology because it is recalcitrant to therapy and has a high risk of recurrence. Among the various risk factors known to play a role in the development of melasma, thyroid dysfunction is common to be found in this condition. This review attempts to gather evidence to quarry the relationship between melasma and thyroid hormone regulation disorders. The available evidence suggests that melasma can be influenced by inflammatory conditions, increased oxidative stress, and stimulation of Adrenocorticotropic hormone (ACTH) and Melanocyte-stimulating hormone (MSH) via the hypothalamic pituitary thyroid (HPT) axis in hyperthyroid conditions. By further understanding the pathophysiological conditions in this disorder, treatment and prevention of melasma progression can be carried out more effectively.