Abstract : An indicator of the quality of handling emergency patients is the speed of assisting (response time). Delay in handling emergency patients can be fatal. One of the causes of errors and delays in providing action to patients in the emergency department is the excessive workload that results in high activity so that the body experiences Fatigue. Physical Fatigue is indicated by decreased reflex motion quality. The decrease in motion reflex impacts the decrease in emergency handling services (response time). The research objective was to identify the effect of nurse fatigue on the response time for handling emergency patients in the Emergency Room during the Covid-19 pandemic. The research method was correlation design with a cross-sectional approach and obtained 21 nurses in the emergency department. The instrument used to measure Fatigue was the Fatigue Severity Scale. The response time for handling emergency patients was installed by an emergency department entirely (100%) according to the time category based on ATS 1,2,3,4,5, with a value median of 57 seconds, which is seen from the response time most of the respondents (52.4%) less than 57 seconds, while the Spearman Rank test analysis obtained p-value 0.600> α 0.05 with a value of r: 0.121, this shows that fatigue effects on the response time for emergency patients, with a very weak positive correlation, which indicates that the higher the degree of Fatigue, the more response time slows down.