Sapporo Medical Journal

Abstract : Background: Since the egression of the coronavirus 2019 (COVID-19) disease, more than 200 countries and areas around the world were affected. To the present, it is not clear whether COVID has effects on thyroid function or not. Object: The target of the current revision is to compare thyroid function in COVID cases with and without history of thyroid illness to find out the thyroid disturbance in both groups. Methods: The present study enrolled 86 COVID affected patients that alienated to groups with and without history of thyroid cases, beside comorbidities with diabetes or hypertension. Thyroid hormones [triiodothyronine (T3) and thyroxine (T4)], thyrotropin (TSH) and thyroid peroxidase (TPO) concentrations were analyzed and assessed. Results: Most of the participants (88.4%) had normal T3 and TPO level, that there was no significant difference (p = 0.069) between groups of with and without history of thyroid disease and/or upraised of TPO antibody level. Also T4 levels of the participants with no history of thyroid disease and normal TPO did not differ significantly (p =0.725) from those with a history of thyroid disease and/or high TPO. Regarding the level of TSH was significant difference (p<0.001) between the patients with high TSH, no history of thyroid disease and normal TPO (0.0%) and those with high TSH, history of thyroid disease and/or high TPO (34.0%). Conclusions: There is high prevalence of subclinical hypothyroidism in the COVID patients with family history of