Abstract : Purpose: To evaluate the potential of autologous activated platelet-rich plasma (aaPRP) and the outcomes for treating severe Coronavirus Disease-2019 (COVID-19) patients in Intensive Care Unit (ICU). Materials and methods: A case series of four patients from Koja Regional Public Hospital (Koja RPH) whom admitted to the ICU due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Results: All patients had the initial symptoms of SARS-Cov-2 infection and became worse overtime, so the patients were admitted to ICU. Dyspnoea with low oxygen saturation was observed in all cases. All patients had comorbids for COVID-19. Severe COVID-19 was observed in all of patients, as they had increasing CRP level and low level of oxygen saturation. The outcome of this case study showed potential effectiveness of aaPRP as adjunctive severe COVID-19 treatment. Conclusion: Autologous activated PRP treatment could be feasible to apply in severe COVID-19 management.