Abstract : P. aeruginosa is an opportunistic microorganism that impose a versatile modifications in its genome to sustain an infection that can range from otitis media to a life threating disease. Moreover, antibiotic resistance endows P. aeruginosa characteristics to be one of the most resistant microorganisms to be treated. P. aeruginosa possess both cell associated and extracellular virulence factors. Cell associated virulence factors include flagellum, pili, adhesins, alginate, and lipopolysaccharide. While, extracellular virulence factors include hemolysins, proteases, lipases, exotoxin A, and cytotoxins.