Abstract : Chronic kidney disease includes conditions that damage the kidneys and decrease their ability to keep them healthy. Kidney disease patients have no symptoms at all. At the worst, patients can be threatened with life if they do not undergo periodic hemodialysis or kidney transplantation to replace their severely damaged kidney organs. CKD patients who reach the final stage will experience a condition that causes disability, poor quality of life, and expensive social and financial costs. The study aimed to identify psychosocial assistance on patients' quality of life with chronic renal failure. This research is a quantitative study using a quasi-experimental method with the one group pre-test-post test design approach. Data collection using the WHOQOL quality of life questionnaire was then carried out psychosocial mentoring. Respondents were patients with chronic renal failure with hemodialysis, amounting to 34 people. The sampling method used purposive sampling. This study indicated that the quality of life significantly increased with p-value = (0.001). Domains that have increased are psychological domain p-value = (0.001) and environmental domain p-value = (0.001). The physical health domain (p = 0.639) and social domain (p = 0.751) did not change significantly. Many psychosocial problems occur in CRF patients with hemodialysis. Urgently needed support from family and community to improve patients' quality of life with hemodialysis with chronic renal failure.