Abstract : Background: Controversy exist as regards the optimum treatment of pituitary adenoma as it is claimed to be spontaneously regressed. The aim of the current case report with literature review is to highlight the reality of the notion that pituitary adenomas might need no treatment nor surgical intervention due to their spontaneous regression. Methods: We presented here with a case of a 47-year-old female who undergone a strict observation and follow up for pituitary adenoma during a period of 10 years. Review of the literature took place as regards this notion. Conclusion: Pituitary adenomas may need no intervention because they may regress spontaneously. Although the data of one patient is limited it may shed the light on the problem. Further cohort series of this rare condition might be needed to properly investigate the condition.