Sapporo Medical Journal

Abstract : Essential hypertension and its complication, a chronic heart failure, are one of the most common pathological tandems in practical cardiology. Linked etiologically and pathogenetically, they share a common path of progression, manifested by structural, functional, and humoral disturbances in cardiovascular homeostasis. In recent years, a member of the family of natriuretic peptides, brain natriuretic peptide, has taken the place of one of the biomarkers of myocardial and vascular remodeling processes, most often used in practical medicine; it is also positioned as a humoral antagonist of the activity of renin-angiotensin-aldosterone system, which is the leading pathogenetic link in most cases of hypertensive cascade and CHF. This study aims to supplement the data on the use of BNP as a signaling indicator of changes in myocardial structure and function and calculate the screening threshold levels of peptide in uncomplicated and complicated EH in postmenopausal women with polymorphic variants of the BNP gene. It was revealed that the frequency of carrying the T381C genotype and the C allele significantly prevails among the polymorphic variants of the BNP gene in women 40-65 years of age. The highest level of plasma BNP concentration, which was 193,27 ± 2,98 pg/ml, was determined in women with EH complicated by CHF. In addition, carrying the C allele of the BNP gene is significantly associated with higher levels of peptide in the blood plasma of women in all the examined groups