Sapporo Medical Journal

Abstract : Cow’s milk protein allergy is an important issue in children because it can lead to growth disorder. This study aims to analyze effect of growth disorder in clinical manifestation of children with cow’s milk protein allergy. A cross sectional study was performed in children with cow’s milk protein allergy between March to April 2018 in Pediatric ward, Dr. Soetomo Hospital, Surabaya, Indonesia. Age, body weight, height, and clinical manifestation of gastrointestinal tract or respiratory tract were recorded from medical record. Data analysis was performed using chi square and odds ratio to determine effect of growth disorder in clinical manifestation of children with cow’s milk protein allergy. Clinical manifestations of gastrointestinal tract were more often had underweight, stunted, and wasted (60%, p < 0,05; 52,9%, p > 0,05; 65,7%, p < 0,05, respectively) compared to clinical manifestation of respiratory tract. The effect of clinical manifestations in children with cow’s milk protein allergy to have underweight and wasted was higher in clinical manifestation of gastrointestinal tract compared to clinical manifestation of respiratory tract (OR 2.455 for underweight and OR 6.024 for wasted). The effect clinical manifestations in children with cow’s milk protein allergy of underweight was 2.455 times higher and wasted was 6.024 times higher in clinical manifestation of gastrointestinal tract.