Abstract : This study examines the sensorial saturation effect and non-nutritive sucking on reducing neonates' pain when undergoing the invasive procedure (infusion) at Rumah Sakit Palang Merah Indonesia ( Indonesian Red Cross Hospital) in Bogor. Quasi-experimental research design with a sample of 15 respondents. The study showed that the heart rate of the two groups significantly increases after comparison. The change of the SaO2 level in the SS Group was lower than the control (NNS). The change of the CRIES score in the SS group was lower than NNS. However, there were statically significant differences between SS and NNS groups (p=0.00). It's suggested that single or combined use SS is effective in reducing pain responses in neonates.