Abstract : This study determines the prevalence and socio-demographic of HIV among tuberculosis patients and intravenous drug users (IDUs) in Hospital Universiti Sains Malaysia (HUSM), Kubang Kerian, Kelantan Malaysia. All the data collected was entered in MS Excel Database. Thereafter data entry and analysis were conducted using Statistical Packages for Social Sciences (SPSS) version 26. The continuous variables were expressed as mean (SD) and categorical variables were expressed as frequencies and percentages. The result showed that The mean age of HIV among tuberculosis patients was 33 years old. Most of the patients were male (82%), Malay (90%), non-Malay patients is 10% only, half of all HIV among TB patients have a low CD4 count of fewer than 200 cells/mm3, 24 percent of HIV cases are reported due to heterosexual, 3% of HIV among TB patients were infected through blood transfusions and most patients were smoker (65%). In conclusion, as the prevalence of TB/HIV coinfection is associated with the prevalence of HIV in the general population, and antiretroviral therapy is effective in treating both diseases, HIV-infected patients should begin treatment as soon as possible.