Abstract : Neuropathic pain is caused by disorder of somatosensory nervous system. It affects mostly in women and older population. The causes of peripheral neuropathic pain are trigeminal neuralgia, diabetes peripheral neuropathy, postherpetic neuralgia and so on. The causes of central neuropathic pain are spinal cord injury, multiple sclerosis, brain tumors and so on. To date, managing neuropathic pain is still challenging to physicians. The available choice of drugs is limited to efficacy and adverse effects. In addition, neuropathic pain has poor response to current medications. Botulinum Toxin type A (BoTN-A), which is produced by Clostridium botulinum, is known as potential analgesia in neuropathic pain. This review aims to outline the efficacy of BoTN-A in some causes of both peripheral and central neuropathic pain. The conclusion of this review is BoTN-A is safe and effective in reducing pain intensity in neuropathic pain

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