Sapporo Medical Journal

Abstract : Transurethral resection of the prostate (TURP) is currently the gold standard procedure for benign prostate hyperplasia (BPH). It may lead to various complications, such as urinary tract infection (UTI). Antibiotic prophylaxis use for TURP in the world has been studied, especially in the high-risk case. We aimed to evaluate the effectiveness of antibiotic prophylaxis in reducing bacteriuria and sepsis incidences on post-TURP patients. A systematic search was conducted in PUBMED, SCIENCE-DIRECT databases. The eligible analysis and article selection followed The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol, analysis of bias used Cochrane Risk of Bias Tools, each was done by 2 independent reviewers. Five RCT articles are declared eligible and involved 872 patients. Forest plot shows data heterogeneity from post-TURP bacteriuria incidence, and there is significant difference between antibiotic prophylaxis and placebo/no therapy (OR=0.38, 95% CI=0.17 – 0.88; p = 0.02). The Forest plot shows data homogeneity from post-TURP sepsis incidence, and there is no significant difference between antibiotic prophylaxis and placebo/no therapy (OR=0.64, 95% CI=0.09 – 4.53; p = 0.66). Post-TURP bacteriuria incidence in patients administered with antibiotic prophylaxis is lower than placebo/no therapy, but post-TURP sepsis incidence in patients administered with antibiotic prophylaxis is the same as placebo/no therapy.