Sapporo Medical Journal

Abstract : BACKGROUND: Resistant hypertension has been identified as one of the causes for hypertensive patients failing to reach their blood pressure target. OBJECTIVE: This study aims to determine the prevalence of resistant hypertension amongst elderly hypertensive patients (aged 60 years and above) and the factors associated with resistant hypertension.METHODOLOGY: A cross-sectional study incorporating a questionnaire was used in this study and was conducted between July 2018 to February 2019. Adherence to anti-hypertensive medication was assessed by using the 14-item Hill-Bone Compliance to High Blood Pressure Therapy Scale. RESULTS: A total of 594 patients aged ≥ 60 years were studied. The mean age was 70.28 ± 6.74 years with 57.8% (n=343) being female. The mean systolic blood pressure was 144.93 ± 14.12 mmHg while the mean diastolic blood pressure was 77.67 ± 8.64 mmHg. The proportion of patients with resistant hypertension was 66.3% (394/594). In univariate analysis, factors found to significantly associated with the presence of resistant hypertension were gender, educational level and age (p<0.05). In multivariate analysis, it was found that older age and those of a lower educational level were determinants of having resistant hypertension. CONCLUSION: The prevalence of resistant hypertension among elderly patients was very high. Groups found to have a higher risk of developing resistant hypertension should be targeted during health campaigns or consultations.

Abstract : Train postpartum skill directly of accompaniment carried out by midwife to empowering the mother in her new duties related to the presence of the baby. The purpose of this study was to know the effect of accompaniment through direct Guidance at real situations in postpartum to her independence on newborns care. Design research was a quasi-experimental study with early postpartum subjects in BPM Midwife S and M at Kemang, Bogor. The research subjects were 35 respondents who received the intervention and 35 respondents as control. In this study, the intervention group received mentoring and Guidance for three days in newborn care. On the 7th day, an assessment of independence in newborn care was carried out. The control group received baby care counseling; it was based on midwifery care standards without assistance. The dependent variable was the mother's independence in newborn care. The independent variable was mentoring for the postpartum. Data analysis was using the Mann-Whitney Test. The result shows that there were significant differences in mother's independence in newborns care between both groups, where the intervention group had better independence. with a mean value of 160.55 ± 75,611 and p=0,000 (<0,005). This study concluded that mentoring of postpartum mothers could increase mother's independence in newborns care. Suggestions from this study were to optimize mentoring for postpartum in newborns care to help mothers to had independent and to optimize the return o

Abstract : Background: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by heterogeneous bleeding manifestations as well as marked-inter individual variation in response to glucocorticoid (GCs); the 1st line ITP treatment. This may be due to Pgp as steroids outside the intracellular space thus decreasing its intracellular concentration. Methods: The study investigated the relation between single nucleotide protein; the product of ATP binding cassette B1( ABCB1) gene. It is involved in effluxing drugs polymorphism (SNPs) in ABCB1gene and the variable response to oral prednisolone treatment in 100 Egyptian ITP patients. Clinical response was measured during 1st 28 days and compared with C3435T and G2677T SNPs determined by PCR REPLF technique. Results: No significant difference in C3435T between ITP patients and control. Carriers of mutant allele of G2677T were significantly higher in ITP patients compared with the control group (p value :02) suggesting possible role in disease predisposition. Conclusion: There was no significant relation between these two SNPs and age of onset of the disease , initial platelet count, response to steroid therapy .

Abstract : The paper focused on the composition of the phytochemistry, the nutrient, and the mineral, and antioxidant activities of Morinda L. grown in three provinces (the central and the south area) in Vietnam. Phytochemistry (flavonoid, triterpenoid, alkaloid, and tannins), nutrient (protein, fat, carbohydrate, and fiber), minerals (Ca2+, Mg2+, Fe3+, Zn2+, Na+, Cu2+), and antioxidant activities (total, reducing power, and DPPH free radical scavenging) of species Morinda L. grown in Binh Phuoc, Khanh Hoa, and Ca Mau province in Vietnam were evaluated and compared. The results showed that the difference in the nutrient, the minerals, and antioxidant activities between species Morinda L. grown in three provinces occurred (p<0.05). The different species and habitats caused different nutrient, minerals, and antioxidant activities. Different phytochemistry appeared in all Noni samples. Antioxidant activities of species Morinda tomentosa grown in Khanh Hoa province was higher than Morinda citrifolia in Binh Phuoc and Ca Mau province. Minerals content decreased in order Binh Phuoc, Khanh Hoa, and Ca Mau. Nutrient content basing on protein content, Morinda L. grown Ca Mau province was evaluated higher than Binh Phuoc and Khanh Hoa.

Abstract : This study aimed to investigate the optimization of acid gamma-aminobutyric (GABA) content biosynthesis in germinated Mung bean. The effect analysis of soak time, germination temperature, and time on GABA content was using the response surface method (RSM), with a central composite design (CCD) with the support of software JMP version 9.0.2. Results showed that GABA content reaches the highest levels of 3.768± 0.041 mg GABA equivalent/g dry matter as soaking the seeds in tap water. GABA content got the highest value of 4.1006± 0.0326 mg GABA equivalent/g dry matter at the optimization condition (soaking time of 8 hours, germination at 34oC for 26 hours in tap water) and increase of 9.362 times, compared to non-treatment Mung bean seeds. Soaking time, germination time, and germination temperature affected on acid gamma-aminobutyric biosynthesis. GABA is useful for application in the functional food and pharmaceuticals containing GABA.