Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Purpose: To evaluate the impact of KRAS mutation type as a predictor of response to different chemotherapy regimens (oxaliplatin-based, Irinotecan based). Methods: This is a retrospective study included 198 patients with metastatic colorectal cancer (mCRC) diagnosed and managed at medical oncology department, clinical oncology department, pathology department, oncology department in Health Insurance hospital, data regard clinicopathological features of the disease, pattern of KRAS mutation and response to chemotherapy is retrospectively collected and analysed. Results: KRAS codon 12 mutations were more common in males while codon 13 mutation that was more common in female patients (P<0.05). Right-sided colon experienced a significantly increased number of KRAS codon 13 mutations, while codon 12 was more in the left side (P<0.05). There was no difference between both treatment arms regard Progression-free survival (PFS), in wild type also there was no difference, but PFS in patients with codon 12 mutation receiving oxaliplatin protocol was statistically significantly higher than patients with codon 13 mutation (P 0.016). In patients with codon 13 KRAS mutation PFS was statistically significantly higher in irinotican arm than in oxaliplatin arm (P 0.001). Conclusion: we can tailor chemotherapy according to the type of mutation as patients with codon 12 mutation gets more benefit with first line oxaliplatin containing protocol, while those with codon 13 mutation gets more be
Abstract : Background: Our aim was to determine the prevalence of depression and anxiety in cancer patients and to correlate depression and anxiety in the patients and their caregivers. Methods: This was a cross-sectional study conducted from 1st of March 2013 to 30th of May 2015. Cancer patients and their caregivers seen in the outpatient clinics and day care unit of King Abdulaziz University Hospital in Jeddah, Saudi Arabia, were included in the study. The data was collected by questionnaires using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) screening tools for depression and anxiety disorder, respectively. Consent was obtained from all participants. The data were analyzed using Statistical Package for the Social Sciences. Descriptive and comparative analyses were done using frequency, chi-square, and Cohen’s kappa. Results: The total study population was 294 participants (147 patients and 147 caregivers). Depression and anxiety were found in 72.2% and 66% of patients and 66% and 42.8% of caregivers, respectively. Agreement between patients and caregivers was statistically significant for many points of the questionnaires (P-value < 0.05). Conclusions: In conclusion, the prevalence of depression and anxiety were high in both cancer patients and their caregivers. More attention should be directed toward detecting psychological changes in these vulnerable individuals. Routine screening along with social support should be included in clinical pr
Abstract : Bacterial meningitis is a life-threatening medical emergency. Cerebrospinal fluid (CSF) culture is a must to identify the pathogens of bacterial meningitis. Still, its result is usually late and sometimes shows low sensitivity, especially due to antibiotics previously given. Latex agglutination test and Gram staining are not sufficiently sensitive. Multiplex real-time PCR assay gives quick diagnostic results with high sensitivity, even with non-viable bacterial agents. The study aimed to evaluate the validity of the combination of different assays in diagnosing bacterial meningitis in Vietnamese children. A cross-sectional study was conducted. CSF culture, latex agglutination test, Gram staining, and multiplex real-time PCR assays were performed. The Kappa statistic was used to calculate the agreement between the methods. Totally, 108 eligible cases were recruited. There were five positive cases (4.6%) isolated by CSF culture, while the multiplex real-time PCR assays identified pathogens in four cases (3.7%). Latex agglutination testing and Gram staining gave positive signals in three different cases. The agreement between multiplex real-time PCR and culture / latex agglutination testing / Gram staining was 0.652 / 0.852 / 0.262 correspondingly by the kappa statistics. The study showed that different diagnostic methods should be used to give accurate results in the determination of infectious agents in CSF specimens causing acute bacterial meningitis in Vietnamese children.
Abstract : Mental health in pregnancy is often forgetten and not integrated with antenatal care in most middle income countries (MICs). Many common mental disorders (anxiety and/or depression) in pregnant women are not well identified and untreatment in MICs. The aim of this review to identify common mental disorders’ predictors and outcomes in pregnancy, and evaluate the implementation of early detection of anxiety and/or depression symptoms in antenatal care in MICs. Sources of this review are from grey literature and scientific articles that have been published between 2009-2020 on Proquest, Science direct, JSTOR, Springer link, PubMed, and EBSCO. The result of this review are: family income, domestic violence, and husband’s low support are dominant predictor factors to cause anxiety disorder and/or depression in pregnancy. Untreated anxiety and/or depression in pregnancy increase risk of depression postpartum, suicidal ideas, and disability for maternal; risk of low birth weight, undernutrition, and stunting for children. On the other hand, early detection for pregnant women’s mental health almost never done in antenatal care in MICs. There are stigma and inequality health service for poor pregnant women makes they more inability to access mental health care.
Abstract : Dental treatment under general anaesthesia (GA) is often indicated in uncooperative paediatric patients with or without the complex dental procedure. Preoperative diagnosis needs to be thoroughly assessed to ensure the dental treatment under GA can be efficient and safely completed by the paediatric dentist and trained anaesthetist. The research aims to determine the common preoperative diagnosis prior dental treatment under GA among paediatric patients in Hospital Universiti Sains Malaysia, and its association to gender. A retrospective review of paediatric dental treatment under GA from 2015 to 2018 was undertaken. A total of 298 patient’s records were retrieved for data collection. Descriptive statistics and multiple response analysis were used to analyze the data. The most common preoperative diagnosis made was early childhood caries (53.1%, n=188), followed by dental caries (25.1%) and dentoalveolar abscess (17.1%). Firstly, the analysis of multiple responses was combined between male and female; the highest diagnosis within four years was ECC diagnosis 188(53.1%) and dental caries 89(25.1%). Second, the result was being separate according to gender. The result indicates that the ECC diagnosis for males; 98(52.7%) and females; 90(53.6%), while dental caries is 49(26.3%) for males and 40(23.8%) for females. This research is beneficial for the better understanding the paediatric dental service, particularly those children who are indicated for dental treatment under GA.